Systemic Lupus Erythematosus (SLE) is the most common type of Lupus. SLE is an autoimmune disorder in which the immune system mistakenly attacks healthy tissues. This can result in pain, inflammation and damage to various tissues/organs within the body. It is most commonly seen in women of childbearing age and the severity can vary widely on a case-by-case basis.
Signs and Symptoms
SLE is known to have a range of symptoms that can either present sporadically in “flare-ups”, or be more persistent in nature. These symptoms include the following:
- Fatigue
- Joint pain and swelling
- Rash/Skin sensitivity: This is often exacerbated by exposure to direct sunlight and is commonly manifested in what is described as a “butterfly rash across the face”
- Loss of appetite and weight loss
- Fever
- Muscle weakness
- Chest pain or shortness of breath: Due to inflammation in the lungs or heart lining.
- Kidney issues: Swelling in the legs or around the eyes, and changes in urine colour or frequency.
- Neurological symptoms: Headaches, confusion, memory problems, or seizures.
Diagnosis
As seen above SLE can present with a wide range of symptoms, hence mimicking other conditions and making diagnosis challenging at times. That being said early diagnosis is important and consultation with your medical team can help start this process.
Diagnosis is based on the presentation of clinical signs and confirmed with further testing, including blood tests. A blood test will involve Anti-Nuclear Antibody (ANA) testing in which the presence of antibodies that may attack healthy tissues in the body is assessed.
Causes
Unfortunately, we are yet to determine the exact cause of SLE but we believe it to be a result of a combination of genetic, hormonal and environmental factors including;
- Genetics: Family history is an indicator of increased risk
- Hormones: Oestrogen is thought to play a role, as SLE is more common in women.
- Environmental triggers: Exposure to sunlight, infections, stress, or certain medications.
Prognosis
It is important to note that the nature of this condition is chronic and at times can be unpredictable, with periods of flare-ups and remission (periods of time where symptoms improve).
That being said the prognosis for people living with SLE has improved significantly due to advances in medical treatment and early diagnosis. Most people with SLE can manage their symptoms and maintain a good quality of life.
Prognosis also depends on the severity of organ involvement, particularly in the kidneys and heart. Early detection and appropriate management are crucial for reducing complications and improving long-term outcomes. With ongoing treatment and lifestyle adjustments, many people with SLE lead active and fulfilling lives.
Treatment
Unfortunately, at this time there is no cure for SLE although there are a range of treatments that can help to manage symptoms and improve quality of life. Treatments may include medications such as;
- Nonsteroidal anti-inflammatory drugs (NSAIDs): To relieve pain and reduce inflammation.
- Corticosteroids: To control inflammation during flares.
- Immunosuppressants: To reduce overactivity of the immune system.
- Antimalarials: To manage skin and joint symptoms and reduce flare frequency.
- Biologic agents: For severe cases not responding to standard treatments.
Physiotherapy and Rehabilitation
Physiotherapy plays a crucial role in the management of SLE, particularly in maintaining mobility, reducing pain, and improving overall function. Physiotherapists can help by:
- Exercise programs: Tailored exercises to enhance muscle strength, joint flexibility, and cardiovascular fitness. Low-impact exercises, such as swimming, walking, and stretching, are particularly beneficial.
- Pain management techniques: Including heat and cold therapy, gentle manual therapy, and relaxation exercises to reduce muscle tension.
- Fatigue management: Developing pacing strategies and energy conservation techniques to help clients manage fatigue more effectively.
- Posture correction and ergonomic advice: To minimise joint strain during daily activities.
- Education and support: Helping clients understand their condition, recognise early signs of flares, and implement self-management strategies.

Additional Management Strategies
- Sun protection: Wearing sunscreen and protective clothing to avoid UV-triggered flares.
- Healthy diet and hydration: To support overall health and reduce inflammation.
- Stress management: Using relaxation techniques to minimise flare triggers.
Sources
Blaess, J., Goepfert, T., Geneton, S., Irenee, E., Gerard, H., Taesch, F., Sordet, C., & Arnaud, L. (2022). Benefits & risks of physical activity in patients with Systemic Lupus Erythematosus: a systematic review of the literature. Seminars in Arthritis and Rheumatism, 58, 152128. https://doi.org/10.1016/j.semarthrit.2022.152128
Branch, N. S. C. a. O. (2025, January 8). Systemic lupus erythematosus (Lupus). National Institute of Arthritis and Musculoskeletal and Skin Diseases.
The Royal Australian College of general Practitioners. (n.d.). Systemic lupus erythmatosus. Australian Family Physician. https://www.racgp.org.au/afp/2013/october/systemic-lupus-erythmatosus
Systemic Lupus Erythematosus. (2023, August 4). National Library of Medicine. https://www.ncbi.nlm.nih.gov/books/NBK535405/